Ear, Nose, Summaries

Novel kinase inhibitor drugs to treat respiratory disease or breast cancer
Alevy, Yael ; Brett, Thomas ; Holtzman, Michael ; Patel, Anand ; Patel, Dhara ; Romero, Arthur
T-011991

— Disease indications: Drug format: small molecule Drug class: first in class Research stage and Preliminary data: Preclinical development of the lead compound for respiratory disease includes in vitro and in vivo efficacy, selectivity and initial toxicity testing. Preclinical development of the…

Low-cost optical sensors for high performance, discrete hearing aids
Liao, Jie ; Yang, Lan
T-019167

— Technology Description A team of engineers in Prof. Lan Yang’s laboratory have developed ultra-sensitive, broad bandwidth optical sensors that could detect sound in low-cost, discrete hearing devices. This technology utilizes whispering gallery mode (WGM) resonators as compact photonic vibra…

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for Adolescents (13-18)
Jeffe, Donna ; Lieu, Judith ; Rachakonda, Tara
T-013745

— The prevalence of hearing loss (HL) in adolescents has grown over the past decade, with rates of 19.5% for HL of >15dB and 5.3% for HL >25dB. Adults with HL are 21% to 39% less likely to have attained postsecondary education than normal-hearing persons and are 1.5 to 2 times more likely to exp…

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for Adolescents (13-18)
Jeffe, Donna ; Lieu, Judith ; Rachakonda, Tara
T-013745

— The prevalence of hearing loss (HL) in adolescents has grown over the past decade, with rates of 19.5% for HL of >15dB and 5.3% for HL >25dB. Adults with HL are 21% to 39% less likely to have attained postsecondary education than normal-hearing persons and are 1.5 to 2 times more likely to exp…

Small molecules targeting KCNQ in ventricular arrhythmia
Cui, Jianmin
T-013554

— Disease indication – Long QT Syndrome (resulting in ventricular arrhythmia, epilepsy, deafness) Drug format – Small molecule Drug class – Lead compounds are repurposed drugs Research stage and preliminary data – Based on in silico screening of KCNQ, the researchers selecte…

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